SnapShot: Pain Perception

SnapShot: Pain Perception

SnapShot: Ion Channels and Pain

Nav1.3 TTX-sensitive, voltagegated sodium channel Embryonic DRG and TG neurons, spinal cord, and thalamus; upregulated in DRG and dorsal horn neurons following nerve injury Loss of function attenuates pain-related behavior Na+ channel blockers including local anesthetics, anticonvulsants, antiarrhythmic, and TCAs relieve pain associated with neuropathy, diabetes, osteoarthritis, and surgery. Mu...

Pain perception in competitive swimmers.

The pain perception of 30 competitive swimmers was studied using experimentally induced ischaemic pain. The pain thresholds and tolerances of this group were compared with those of 30 club swimmers and 26 non-competitive athletes. While pain thresholds showed little difference between the groups, pain tolerances were considerably different. Pain tolerances of the competitive swimmers varied acc...

Sleep deprivation and pain perception.

Chronically painful conditions are frequently associated with sleep disturbances, i.e. changes in sleep continuity and sleep architecture as well as increased sleepiness during daytime. A new hypothesis, which has attracted more and more attention, is that disturbances of sleep cause or modulate acute and chronic pain. Since it is well-known that pain disturbs sleep the relationship between the...

Pain perception and electromagnetic fields.

A substantial body of evidence has accumulated showing that exposure to electromagnetic fields (EMFs) affects pain sensitivity (nociception) and pain inhibition (analgesia). Consistent inhibitory effects of acute exposures to various EMFs on analgesia have been demonstrated in most studies. This renders examinations of changes in the expression of analgesia and nociception a particularly valuab...